In a large mixing bowl, add the chicken tenders, buttermilk, Worcestershire sauce and seasonings (paprika, onion powder, garlic powder, salt, black pepper, and cayenne pepper). Mix thoroughly, cover bowl and refrigerate for 2-4 hours or overnight. Remove marinated chicken from the fridge about 30 minutes before dredging and frying to bring to room temperature.
Line a large baking sheet with parchment paper. Set aside. In a separate large mixing bowl, add and mix together the flour, cornstarch and seasonings (paprika, onion powder, garlic powder, salt, black pepper, and cayenne pepper).
Drizzle 2 to 3 tablespoons of the marinade into the dredge mixture and mix to form a crumbly texture.
Working with one piece of chicken at a time, thoroughly dredge all sides in the flour mixture, fully dip the tender back into the marinade and then back into the flour mixture for a double coat. Transfer the double coated chicken tender to prepared baking sheet. Repeat with remaining chicken tenders.
Rest the coated chicken tenders for 8 to 10 minutes. As the chicken rest, heat oil in a large skillet or pan to 350F (highly recommend using a kitchen thermometer, if you have one).
In batches, fry the tenders, about 3 to 5 minutes per side or longer as needed until the internal temperature reaches 165°F. Transfer fried tenders to a wire rack placed over a paper towel lined baking sheet to catch any excess oil.
Serve tenders immediately while still hot and crispy. Enjoy!